chemotherapy drugs old and most recent are available. Their intent is to
kill/freeze cancer cells for a certain amount of time.
The use of a
single or a combination of agents that can be given in association, before,
later or in alternative of RT depends by several factors that include the
type/grading of tumour and the clinical features/age of the patient.
The most common
agents used in brain tumor are:
Nitrosoureas: Lomustine (CCNU), Carmustine (BCNU)
Alkylating-methylating agent: Temozolomide (TMZ)
agents: Cisplatin, Carboplatin,
topoisomerase II: Etoposide
topoisomerase I: CPT-11
biologic therapies under clinical evaluation: tyrosine kinase receptor
inhibitors, epidermal growth factor receptor inhibitors, farnesyl
transferase inhibitors, antiangiogenesis agents…