Astrocytoma 2
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Astrocytoma 1
Astrocytoma 2
Astrocytoma 3
Astrocytoma 4

WHO Grade II Astrocytomas

Slowly growing tumours that show a tendency towards malignisation over time.  Growth at the time of diagnosis, extent of surgical removal, and timeliness and effectiveness of follow-up therapy are important determinants for prognosis.

Treatment: the treatment of choice is surgical removal to the maximum extent possible without causing neurological deficit, though on occasion simple observation may be opted for in order to track growth.  Radiation is indicated in cases of partial removal when the tumour is surgically inaccessible or not amenable to removal, and in cases of malignant transformation.  Chemotherapy reserved for cases of tumour progression.

Prognosis: the time to malignant transformation and/or recurrence from the moment of first diagnosis varies from about half a year to five years, with life expectancy from that point onwards ranging from about one to six years.

Protoplasmic astrocytoma:

They display a predilection for being cortically based, often in the temporal and frontal lobes, and are frequently accompanied by a long history of seizures.

Gemistocytic astrocytoma:

Generally located in the cerebral hemispheres, they tend to be more aggressive than the other Grade II astrocytomas.  Histopathologically they border between low-grade and anaplastic astrocytomas.

Fibrillary astrocytoma:

They comprise the vast majority of primary brain tumours in adults.  Although usually located in the cerebral hemispheres, they may occur anywhere in the central nervous system.

Mixed astrocytoma:

They may contain elements of two or more types of low-grade astrocytomas in various combinations.

last changed 26/05/2011.

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